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KMID : 0948320030030010028
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Konyang Medical Journal
2003 Volume.3 No. 1 p.28 ~ p.33
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Expression of Cyclooxygenase-2(Cox-2) and Vascular Endothelial Growth Factor (VEGF) in Breast Tumors
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Song Hyuk
Koo Tae-Young
Park Ji-Hoon
Song Ki-Hak
Kim Sung-Tae
Kim Yoon-Mee
Kim Bum-Kyeong
Jeong Young-Gil
Yoon Dae-Sung
Choi In-Seok
Choi Won-Jun
Mok Woo-Kyun
Min Hyun-Sik
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Abstract
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Cyclooxygenase (COX)-2 is well- studied target as a chemoprevention and treatment on cancer. Interestingly, a number of cancers appear to over express the COX-2 enzyme, which may play several roles in carcino genesis. Recently there were many clinical studies have demonstrated the effect of COX-2 inhibitors in the treatment of cancer, especially, colorectal cancer. Ongoing clinical trials with COX-2 inhibitors will be applied on many other cancer, breast cancer ect. In this study, we examed the expression of Cox-2 and VEGF in 5 common breast tissues. All breast tissues showed expression Cox-2 and VEGF but invasive ductal carcinoma expressed high level significantly. High Cox-2 expression was related with many clinicopathologic factors(c-erb B2 positive, ER positive, low histological grade, p53 negative, negative lymph node metastasis) and the correlation of Cox-2 and VEGF was definiterly positive(p<0.05).
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KEYWORD
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Cox-2, VEGF, Breast cancer,
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